Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.53 |
| ▸ | MAP3K14 | Q99558 | 9/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 10/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28986237 | 1.00 | MAPKAPK2 (0.53) | MAPKAPK2MAP3K14PTK2AURKADAPK3 | |
| SCHEMBL28986292 | 0.87 | MAP3K14 (0.56) | MAPKAPK2MAP3K14PTK2 | |
| SCHEMBL30219609 | 0.87 | MAP3K14 (0.56) | MAPKAPK2MAP3K14PTK2 | |
| SCHEMBL30219552 | 0.83 | MAPKAPK2 (0.56) | MAPKAPK2MAP3K14LCK | |
| SCHEMBL28986278 | 0.83 | MAPKAPK2 (0.56) | MAPKAPK2MAP3K14LCK | |
| SCHEMBL30219630 | 0.83 | MAPKAPK2 (0.47) | MAPKAPK2MAP3K14PTK2 | |
| SCHEMBL30219632 | 0.81 | MAPKAPK2 (0.56) | MAPKAPK2MAP3K14LCKKDR | |
| SCHEMBL28986263 | 0.81 | MAPKAPK2 (0.56) | MAPKAPK2MAP3K14LCKKDR | |
| SCHEMBL28986228 | 0.80 | MAP3K14 (0.53) | MAPKAPK2MAP3K14PTK2JAK2FGFR1 | |
| SCHEMBL30219605 | 0.80 | MAP3K14 (0.53) | MAPKAPK2MAP3K14PTK2JAK2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109810110-B | Compound with 2-aminopyrimidine structure, preparation method and application thereof | 中国科学院上海药物研究所 | 2023-01-24 | — | — | CN | disclosed |