Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 20/20 | 0.77 |
| ▸ | PGR | P06401 | 3/20 | 0.67 |
| ▸ | AR | P10275 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2901558 | 1.00 | NR3C1 (0.77) | NR3C1PGRAR | |
| SCHEMBL2901729 | 0.89 | NR3C1 (0.77) | NR3C1PGRAR | |
| SCHEMBL2893524 | 0.89 | NR3C1 (0.77) | NR3C1PGRAR | |
| SCHEMBL2896413 | 0.87 | NR3C1 (1.00) | NR3C1PGRAR | |
| SCHEMBL12592964 | 0.87 | NR3C1 (1.00) | NR3C1PGRAR | |
| SCHEMBL12592854 | 0.85 | NR3C1 (0.78) | NR3C1PGRAR | |
| SCHEMBL2900186 | 0.85 | NR3C1 (0.78) | NR3C1PGRAR | |
| SCHEMBL2901550 | 0.85 | NR3C1 (0.77) | NR3C1PGRAR | |
| SCHEMBL12592875 | 0.85 | NR3C1 (0.77) | NR3C1PGRAR | |
| SCHEMBL12592892 | 0.85 | NR3C1 (0.77) | NR3C1PGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968577-B2 | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-06-28 | — | — | US | disclosed |
| US-20100063051-A1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2010-03-11 | — | — | US | disclosed |
| WO-2008057862-A2 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063051-A1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF | NFRKB, NFKB2, NFKBIA | NR3C1 10/4885PGR 2096/4885AR 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.