Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.35 |
| ▸ | KIT | P10721 | 4/20 | 0.35 |
| ▸ | FLT3 | P36888 | 4/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.33 |
| ▸ | MERTK | Q12866 | 5/20 | 0.33 |
| ▸ | AXL | P30530 | 3/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.32 |
| ▸ | TTK | P33981 | 2/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19950412 | 0.88 | MAP4K1 (0.36) | MAP4K1NTRK1KITFLT3TYRO3 | |
| SCHEMBL29746687 | 0.88 | MAP4K1 (0.36) | MAP4K1NTRK1KITFLT3TYRO3 | |
| SCHEMBL19950513 | 0.86 | MAP4K1 (0.37) | MAP4K1NTRK1KITFLT3TYRO3 | |
| SCHEMBL29746418 | 0.86 | MAP4K1 (0.37) | MAP4K1NTRK1KITFLT3TYRO3 | |
| SCHEMBL28988366 | 0.83 | MAP2K4 (0.42) | TYRO3MERTKAXLMAP2K4TTK | |
| SCHEMBL19960726 | 0.80 | MAP4K1 (0.40) | MAP4K1NTRK1KITFLT3MAP2K4 | |
| SCHEMBL19950162 | 0.80 | MAP4K1 (0.44) | MAP4K1NTRK1KITFLT3TYRO3 | |
| SCHEMBL29746530 | 0.80 | MAP4K1 (0.44) | MAP4K1NTRK1KITFLT3TYRO3 | |
| SCHEMBL19950375 | 0.79 | MAP4K1 (0.43) | MAP4K1NTRK1KITFLT3MAP2K4 | |
| SCHEMBL29746563 | 0.79 | MAP4K1 (0.43) | MAP4K1NTRK1KITFLT3MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115819417-A | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |