Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 8/20 | 0.36 |
| ▸ | TTK | P33981 | 3/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19950475 | 0.86 | ALDH1A1 (0.40) | MAP2K4CREBBPTTKUSP30RET | |
| SCHEMBL28988367 | 0.83 | MAP4K1 (0.35) | MAP2K4GPR119TTKAXLTYRO3 | |
| SCHEMBL24148625 | 0.77 | AXL (0.46) | MAP2K4GPR119CREBBPTTKUSP30 | |
| SCHEMBL19960726 | 0.76 | MAP4K1 (0.40) | MAP2K4TTKUSP30GSK3BDYRK1A | |
| SCHEMBL29746563 | 0.74 | MAP4K1 (0.43) | MAP2K4CREBBPTTKRETBRD4 | |
| SCHEMBL19950375 | 0.74 | MAP4K1 (0.43) | MAP2K4CREBBPTTKRETBRD4 | |
| SCHEMBL19950487 | 0.74 | MAP4K1 (0.37) | MAP2K4TTKGSK3BDYRK1A | |
| SCHEMBL29746558 | 0.74 | MAP4K1 (0.37) | MAP2K4TTKGSK3BDYRK1A | |
| SCHEMBL29746725 | 0.74 | MAP4K1 (0.40) | MAP2K4CREBBPTTKRETBRD4 | |
| SCHEMBL19950639 | 0.74 | MAP4K1 (0.40) | MAP2K4CREBBPTTKRETBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115819417-A | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |