Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288501 | 0.90 | KDM4E (0.71) | KDM4EALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL3418775 | 0.87 | KDM4E (1.00) | KDM4EALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL289613 | 0.85 | KDM4E (0.78) | KDM4EALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL288846 | 0.82 | KDM4E (0.84) | KDM4EALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL289704 | 0.79 | KDM4E (0.79) | KDM4EALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL289248 | 0.78 | KDM4E (0.77) | KDM4EALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL288141 | 0.76 | KDM4E (0.78) | KDM4EALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL289644 | 0.75 | KDM4E (0.74) | KDM4EALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL3059795 | 0.74 | KDM4E (0.76) | KDM4EALDH1A1GAASMN1; SMN2KMT2A | |
| SCHEMBL12892635 | 0.74 | MEN1 (0.42) | KDM4EALDH1A1GAASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |