SCHEMBL28993095

SCHEMBL28993095

O=C(C=Cc1ccccc1)Oc1ccc(Cl)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.71
CYP1B1 Q16678 1/20 0.60
MAPT P10636 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
MAOB P27338 3/20 0.56
EGFR P00533 1/20 0.55
MMP1 P03956 1/20 0.55
MMP2 P08253 1/20 0.55
MMP9 P14780 1/20 0.55
LMNA P02545 3/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
ALDH1A1 P00352 1/20 0.53
MEN1 O00255 1/20 0.52
CYP1A2 P05177 1/20 0.52
PPARG P37231 1/20 0.51
MAOA P21397 1/20 0.50
HDAC3 O15379 1/20 0.50
TNKS O95271 1/20 0.50
HDAC4 P56524 1/20 0.50
HDAC1 Q13547 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10513868 1.00 KMT2A (0.71) KMT2ACYP1B1MAPTL3MBTL1MAOB
SCHEMBL7698745 0.93 KMT2A (0.66) KMT2ACYP1B1MAPTL3MBTL1MAOB
SCHEMBL7698747 0.93 KMT2A (0.66) KMT2ACYP1B1MAPTL3MBTL1MAOB
SCHEMBL28993133 0.92 MAOB (0.63) KMT2ACYP1B1MAPTMAOBEGFR
SCHEMBL16982630 0.91 KMT2A (0.83) KMT2ACYP1B1MAPTMAOBLMNA
Phenyl Cinnamate SCHEMBL1055160 0.87 KMT2A (0.77) KMT2ACYP1B1MAPTL3MBTL1MAOB
Phenyl Cinnamate SCHEMBL1055161 0.87 KMT2A (0.77) KMT2ACYP1B1MAPTL3MBTL1MAOB
SCHEMBL16968133 0.85 MAOB (0.61) KMT2AMAPTMAOBMMP1MMP2
SCHEMBL27220285 0.85 KMT2A (0.73) KMT2AMAPTMAOBLMNASMN1; SMN2
SCHEMBL28903591 0.84 KMT2A (0.78) KMT2AMAPTMAOBLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116023202-A Synthetic method of alpha-chlorarone derivative 西南大学 2023-04-28 CN claimed
CN-116023202-A Synthetic method of alpha-chlorarone derivative 西南大学 2023-04-28 CN disclosed