SCHEMBL28903591

SCHEMBL28903591

O=C(O)/C=C/c1ccc(OC(=O)/C=C/c2ccccc2)cc1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.78
HCAR2 Q8TDS4 2/20 0.68
HDAC3 O15379 1/20 0.68
TNKS O95271 1/20 0.68
HDAC4 P56524 1/20 0.68
HDAC1 Q13547 1/20 0.68
HDAC7 Q8WUI4 1/20 0.68
HDAC2 Q92769 1/20 0.68
HDAC10 Q969S8 1/20 0.68
HDAC11 Q96DB2 1/20 0.68
HDAC8 Q9BY41 1/20 0.68
TNKS2 Q9H2K2 1/20 0.68
HDAC6 Q9UBN7 1/20 0.68
HDAC9 Q9UKV0 1/20 0.68
HDAC5 Q9UQL6 1/20 0.68
THRB P10828 1/20 0.61
ATM Q13315 1/20 0.61
SRD5A2 P31213 1/20 0.59
MAOA P21397 1/20 0.55
MAOB P27338 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16982630 0.93 KMT2A (0.83) KMT2AHCAR2HDAC3TNKSHDAC4
Phenyl Cinnamate SCHEMBL1055160 0.89 KMT2A (0.77) KMT2AHCAR2HDAC3TNKSHDAC4
Phenyl Cinnamate SCHEMBL1055161 0.89 KMT2A (0.77) KMT2AHCAR2HDAC3TNKSHDAC4
SCHEMBL149407 0.88 CA12 (0.72) KMT2AHCAR2THRBATMSRD5A2
SCHEMBL21791873 0.88 KMT2A (1.00) KMT2AHCAR2HDAC3TNKSHDAC4
SCHEMBL27220137 0.88 KMT2A (1.00) KMT2AHCAR2HDAC3TNKSHDAC4
SCHEMBL5966380 0.88 CA12 (0.72) KMT2AHCAR2THRBATMSRD5A2
SCHEMBL679710 0.88 CA12 (0.72) KMT2AHCAR2THRBATMSRD5A2
SCHEMBL8936562 0.87 KMT2A (0.74) KMT2AHCAR2HDAC3TNKSHDAC4
SCHEMBL24929910 0.86 THRB (0.83) KMT2AHDAC3HDAC1HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115088734-A Composition of saponin and plant extract Y&B妈妈之选有限公司 2022-09-23 CN claimed
CN-117476126-B Propolis flavone extraction method for targeted preparation of uric acid-reducing activity and application 中国农业科学院蜜蜂研究所 2024-03-19 CN disclosed
CN-117476126-A Propolis flavone extraction method for targeted preparation of uric acid-reducing activity and application 中国农业科学院蜜蜂研究所 2024-01-30 CN disclosed
CN-115088734-A Composition of saponin and plant extract Y&B妈妈之选有限公司 2022-09-23 CN disclosed