Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MC4R | P32245 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913456 | 0.86 | GAA (0.66) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2911952 | 0.74 | MAPT (0.68) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2910438 | 0.73 | MEN1 (0.63) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24532111 | 0.73 | MEN1 (0.61) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29680909 | 0.73 | MEN1 (0.61) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24532867 | 0.72 | MAPT (0.58) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29681249 | 0.72 | MAPT (0.57) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24532143 | 0.72 | MAPT (0.57) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24532295 | 0.71 | MEN1 (0.55) | MAPTMEN1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL29681119 | 0.71 | MEN1 (0.55) | MAPTMEN1KMT2ASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166852-A1 | THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES | Helicon Therapeutics, Inc. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154438-A1 | THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES | HELICON THERAPEUTICS, INC. (US) | 2008-12-18 | — | — | WO | disclosed |