SCHEMBL28995377

SCHEMBL28995377

CCCSc1c(Br)cc(N)cc1C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
AR P10275 2/20 0.38
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA7 P43166 1/20 0.34
CA9 Q16790 1/20 0.34
CA13 Q8N1Q1 1/20 0.34
MAPT P10636 2/20 0.34
GAA P10253 2/20 0.33
GLA P06280 1/20 0.33
POLB P06746 1/20 0.33
TSHR P16473 1/20 0.33
ADRB2 P07550 5/20 0.33
KDM4E B2RXH2 1/20 0.32
APLNR P35414 1/20 0.31
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28995318 0.83 AR (0.39) ARCA12CA1CA2CA7
SCHEMBL28995328 0.81 AR (0.38) ARCA12CA1CA2CA7
SCHEMBL28995401 0.76 MAPT (0.45) ARMAPTGAAGLAPOLB
SCHEMBL28995308 0.74 AR (0.40) ARCA12CA1CA2CA7
SCHEMBL29115254 0.71 GAA (0.35) MAPTGAAGLAPOLBTSHR
SCHEMBL2438192 0.69 GAA (0.59) CA12CA1CA2CA7CA9
SCHEMBL15871381 0.69 GAA (0.42) ARCA12CA1CA2CA7
SCHEMBL30688815 0.69 GAA (0.42) ARCA12CA1CA2CA7
SCHEMBL8673787 0.68 ALDH1A1 (0.39) ARCA12CA1CA2CA7
SCHEMBL28598627 0.68 GAA (0.45) ARCA12CA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115703726-B Trifluoromethyl phenyl sulfide compound 上海泰初化工技术有限公司 2024-04-02 CN disclosed
CN-115703726-A Trifluoromethyl phenyl sulfide compound 上海泰初化工技术有限公司 2023-02-17 CN disclosed