Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 7/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | F13A1 | P00488 | 3/20 | 0.38 |
| ▸ | TGM1 | P22735 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28996991 | 0.92 | TGM2 (0.46) | TGM2NPC1RAB9ATRPV1EGFR | |
| SCHEMBL28996930 | 0.91 | TGM2 (0.54) | TGM2HDAC8HDAC6NPC1RAB9A | |
| SCHEMBL28996932 | 0.91 | TGM2 (0.54) | TGM2HDAC8HDAC6NPC1RAB9A | |
| SCHEMBL29370301 | 0.91 | TGM2 (0.54) | TGM2HDAC8HDAC6NPC1RAB9A | |
| SCHEMBL28996928 | 0.91 | TGM2 (0.54) | TGM2HDAC8HDAC6NPC1RAB9A | |
| SCHEMBL25411746 | 0.89 | KMT2A (0.47) | TGM2NPC1RAB9ATRPV1EGFR | |
| SCHEMBL29370548 | 0.89 | KMT2A (0.47) | TGM2NPC1RAB9ATRPV1EGFR | |
| SCHEMBL29369857 | 0.88 | TGM2 (0.42) | TGM2NPC1RAB9AEGFRITK | |
| SCHEMBL26123112 | 0.88 | TGM2 (0.42) | TGM2NPC1RAB9AEGFRITK | |
| SCHEMBL25413281 | 0.87 | TGM2 (0.56) | TGM2TRPV1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116057042-A | Acrylamide-substituted indane compounds and their therapeutic uses | 赛诺菲 | 2023-05-02 | — | — | CN | claimed |
| CN-116057042-B | Acrylamide-substituted indane compounds and their therapeutic uses | 赛诺菲 | 2024-10-18 | — | — | CN | disclosed |
| CN-116057042-A | Acrylamide-substituted indane compounds and their therapeutic uses | 赛诺菲 | 2023-05-02 | — | — | CN | disclosed |