Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCLK1 | O15075 | 1/20 | 0.58 |
| ▸ | FES | P07332 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.58 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.58 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.58 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.58 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.58 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.58 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2903895 | 0.96 | NR3C1 (0.58) | DCLK1FESPIM1CDK2GSK3A | |
| SCHEMBL12592547 | 0.94 | CSNK1D (0.55) | DCLK1FESPIM1CDK2GSK3A | |
| SCHEMBL2896133 | 0.89 | DCLK1 (0.53) | DCLK1FESPIM1CDK2GSK3A | |
| SCHEMBL12592702 | 0.89 | DYRK1A (0.58) | DYRK1AFSCN1POLBNPC1RAB9A | |
| SCHEMBL2899038 | 0.88 | DYRK1A (0.57) | DYRK1AFSCN1CSNK1DPOLBNPC1 | |
| SCHEMBL2899602 | 0.85 | SCD (0.64) | DYRK1ACSNK1DPOLBNPC1RAB9A | |
| SCHEMBL2900198 | 0.85 | NPC1 (0.63) | DYRK1ACSNK1DPOLBNPC1RAB9A | |
| SCHEMBL2901226 | 0.85 | NR3C1 (0.56) | DYRK1AFSCN1CSNK1DNPC1RAB9A | |
| SCHEMBL2898821 | 0.84 | CSNK1D (0.59) | DCLK1FESPIM1CDK2GSK3A | |
| SCHEMBL2900354 | 0.83 | NR3C1 (0.64) | CSNK1DPOLBNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968577-B2 | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-06-28 | — | — | US | disclosed |
| US-20100063051-A1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063051-A1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF | NFRKB, NFKB2, NFKBIA | DCLK1 3884/4885FES 2395/4885PIM1 1022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.