Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 6/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2899738 | 1.00 | GPR183 (0.51) | GPR183HRH3KCNH2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2902873 | 0.88 | ALDH1A1 (0.60) | GPR183ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL2902877 | 0.88 | ALDH1A1 (0.60) | GPR183ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL2905291 | 0.86 | GAA (0.57) | GPR183HRH3ALDH1A1NPC1RAB9A | |
| SCHEMBL2905287 | 0.86 | GAA (0.57) | GPR183HRH3ALDH1A1NPC1RAB9A | |
| SCHEMBL2904853 | 0.86 | MEN1 (0.58) | GPR183ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2904849 | 0.86 | MEN1 (0.58) | GPR183ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2896756 | 0.83 | GPR183 (0.56) | GPR183KCNH2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2896752 | 0.83 | GPR183 (0.56) | GPR183KCNH2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2904962 | 0.82 | GPR183 (0.45) | GPR183HRH3ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010506-B1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-04 | — | — | EP | disclosed |