Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 7/20 | 0.42 |
| ▸ | DPP4 | P27487 | 8/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.37 |
| ▸ | FAP | Q12884 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290171 | 0.90 | CTSC (0.45) | CTSC | |
| SCHEMBL289949 | 0.89 | CTSC (0.44) | CTSC | |
| SCHEMBL290044 | 0.89 | CTSC (0.44) | CTSCDPP4DPP8DPP9DPP7 | |
| SCHEMBL290338 | 0.87 | CTSC (0.44) | CTSCDPP4DPP8DPP9DPP7 | |
| SCHEMBL290567 | 0.81 | CTSC (0.51) | CTSC | |
| SCHEMBL288811 | 0.80 | CTSC (0.49) | CTSCDPP4ACACB | |
| SCHEMBL289369 | 0.79 | CTSC (0.53) | CTSC | |
| SCHEMBL289754 | 0.79 | CTSC (0.52) | CTSC | |
| SCHEMBL299868 | 0.78 | CTSC (0.47) | CTSC | |
| SCHEMBL299206 | 0.78 | CTSC (0.53) | CTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427445-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | AstraZeneca AB (SE) | 2012-03-14 | — | — | EP | claimed |
| EP-2427445-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | AstraZeneca AB (SE) | 2012-03-14 | — | — | EP | disclosed |