Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.46 |
| ▸ | SCN4A | P35499 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29001992 | 1.00 | NPC1 (0.58) | NPC1LMNANPSR1L3MBTL1MEN1 | |
| SCHEMBL27134353 | 0.93 | NPC1 (0.59) | NPC1LMNANPSR1L3MBTL1MEN1 | |
| SCHEMBL26976715 | 0.93 | NPC1 (0.59) | NPC1LMNANPSR1L3MBTL1MEN1 | |
| SCHEMBL655760 | 0.79 | NPC1 (0.44) | NPC1LMNANPSR1L3MBTL1MEN1 | |
| SCHEMBL655761 | 0.79 | NPC1 (0.44) | NPC1LMNANPSR1L3MBTL1MEN1 | |
| SCHEMBL30447445 | 0.78 | USP30 (0.48) | NPC1LMNANPSR1L3MBTL1MEN1 | |
| SCHEMBL17474759 | 0.76 | NPC1 (0.80) | NPC1LMNANPSR1L3MBTL1MEN1 | |
| SCHEMBL17474788 | 0.76 | NPC1 (0.80) | NPC1LMNANPSR1L3MBTL1MEN1 | |
| SCHEMBL2389717 | 0.76 | NPC1 (0.77) | NPC1LMNANPSR1L3MBTL1MEN1 | |
| SCHEMBL2525285 | 0.76 | NPC1 (0.77) | NPC1LMNANPSR1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858925-B2 | GAS41 inhibitors and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-01-02 | — | — | US | disclosed |
| EP-4178571-A1 | GAS41 INHIBITORS AND METHODS OF USE THEREOF | The Regents Of The University Of Michigan (US) | 2023-05-17 | — | — | EP | disclosed |
| CN-116113406-A | GAS41 inhibitors and methods of use thereof | 密歇根大学董事会 | 2023-05-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11858925-B2 | GAS41 inhibitors and methods of use thereof | GAS6, HIF1AN, TMEM41B | NPC1 3567/4885LMNA 4501/4885NPSR1 2583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.