Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | ASPH | Q12797 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | NNMT | P40261 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24854145 | 0.81 | MC4R (0.41) | AKR1C3AKR1C2NNMT | |
| SCHEMBL30318715 | 0.81 | MC4R (0.41) | AKR1C3AKR1C2NNMT | |
| SCHEMBL30340511 | 0.81 | MC4R (0.41) | AKR1C3AKR1C2NNMT | |
| SCHEMBL24094514 | 0.81 | MC4R (0.41) | AKR1C3AKR1C2NNMT | |
| SCHEMBL24094499 | 0.81 | NNMT (0.40) | MEN1KMT2AAKR1C3AKR1C2NNMT | |
| SCHEMBL24094529 | 0.81 | MC4R (0.41) | AKR1C3AKR1C2NNMT | |
| SCHEMBL29002109 | 0.79 | NNMT (0.47) | MEN1KMT2AAKR1C3AKR1C2POLB | |
| SCHEMBL24853336 | 0.78 | NNMT (0.40) | MEN1KMT2AAKR1C3AKR1C2NNMT | |
| SCHEMBL24094566 | 0.78 | NNMT (0.40) | MEN1KMT2AAKR1C3AKR1C2NNMT | |
| SCHEMBL24853335 | 0.78 | NNMT (0.40) | MEN1KMT2AAKR1C3AKR1C2NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116113635-B | Spiro compounds as melanocortin 4 receptor antagonists and uses thereof | 辉瑞公司 | 2025-03-18 | — | — | CN | disclosed |
| CN-116113635-A | Spiro compounds as melanocortin 4 receptor antagonists and uses thereof | 辉瑞公司 | 2023-05-12 | — | — | CN | disclosed |
| EP-4161927-A1 | SPIRO COMPOUNDS AS MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | Pfizer Inc. (US) | 2023-04-12 | — | — | EP | disclosed |