Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 17/20 | 1.00 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.76 |
| ▸ | ROS1 | P08922 | 3/20 | 0.76 |
| ▸ | FLT4 | P35916 | 3/20 | 0.76 |
| ▸ | KDR | P35968 | 3/20 | 0.76 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.76 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.76 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.76 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.76 |
| ▸ | CDK7 | P50613 | 2/20 | 0.76 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.76 |
| ▸ | CDK1 | P06493 | 2/20 | 0.76 |
| ▸ | FES | P07332 | 2/20 | 0.76 |
| ▸ | FER | P16591 | 2/20 | 0.76 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.76 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.76 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.76 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.76 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.76 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857070 | 0.86 | CDK8 (1.00) | CDK8MAP4K4ROS1FLT4KDR | |
| SCHEMBL299518 | 0.84 | CDK8 (1.00) | CDK8MAP4K4ROS1FLT4KDR | |
| SCHEMBL30368585 | 0.84 | CDK8 (1.00) | CDK8MAP4K4ROS1FLT4KDR | |
| SCHEMBL298301 | 0.82 | CDK8 (0.68) | CDK8MAP4K4ROS1FLT4KDR | |
| SCHEMBL298331 | 0.80 | CDK8 (0.67) | CDK8MAP4K4ROS1FLT4KDR | |
| SCHEMBL857910 | 0.78 | CDK8 (0.76) | CDK8MAP4K4ROS1FLT4KDR | |
| SCHEMBL13702375 | 0.78 | HDAC8 (0.68) | CDK8MAP4K4 | |
| SCHEMBL31064962 | 0.77 | RIPK1 (0.69) | CDK8MAP4K4ROS1FLT4KDR | |
| SCHEMBL4165829 | 0.77 | RIPK1 (0.69) | CDK8MAP4K4ROS1FLT4KDR | |
| SCHEMBL857038 | 0.77 | CDK8 (0.69) | CDK8MAP4K4ROS1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115991705-B | 3- (1H pyrrolo [2,3-b ] pyridin-5-yl) benzoyl derivatives, preparation and application thereof | 安徽医科大学 | 2025-04-08 | — | — | CN | disclosed |
| CN-115991705-A | 3- (1H pyrrolo [2,3-b ] pyridin-5-yl) benzoyl derivatives, preparation and application thereof | 安徽医科大学 | 2023-04-21 | — | — | CN | disclosed |