Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Triclopyr. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triclopyr SCHEMBL37162 | 0.94 | TDP1 (0.45) | KDM4EPKMHTTTDP1KMT2A | |
| Triclopyr SCHEMBL29350609 | 0.94 | TDP1 (0.45) | KDM4EPKMHTTTDP1KMT2A | |
| Triclopyr SCHEMBL149659 | 0.94 | TDP1 (0.45) | KDM4EPKMHTTTDP1KMT2A | |
| Triclopyr SCHEMBL29157738 | 0.92 | TDP1 (0.44) | KDM4EPKMHTTTDP1KMT2A | |
| Triclopyr SCHEMBL28924114 | 0.92 | TDP1 (0.44) | KDM4EPKMHTTTDP1KMT2A | |
| Triclopyr SCHEMBL25394124 | 0.92 | TDP1 (0.44) | KDM4EPKMHTTTDP1KMT2A | |
| Triclopyr SCHEMBL27754379 | 0.92 | TDP1 (0.44) | KDM4EPKMHTTTDP1KMT2A | |
| Triclopyr SCHEMBL29225326 | 0.92 | TDP1 (0.44) | KDM4EPKMHTTTDP1KMT2A | |
| Triclopyr SCHEMBL4149847 | 0.92 | TDP1 (0.44) | KDM4EPKMHTTTDP1KMT2A | |
| Triclopyr SCHEMBL23633000 | 0.89 | KDM4E (0.45) | KDM4EPKMHTTTDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118234723-A | Pesticidally active heterocyclic derivatives with sulfoximine containing substituents | 先正达农作物保护股份公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-116298309-B | High throughput cloning of paired bipartite immunoreceptor polynucleotides and uses thereof | 根路径基因组学公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-112585808-B | 2-liquid curable resin composition for battery encapsulation | 第一工业制药株式会社 | 2023-08-22 | — | — | CN | disclosed |
| CN-116298309-A | High throughput cloning of paired bipartite immunoreceptor polynucleotides and uses thereof | 根路径基因组学公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-116144706-A | High throughput cloning of paired bipartite immunoreceptor polynucleotides and uses thereof | 根路径基因组学公司 | 2023-05-23 | — | — | CN | disclosed |