Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL985457 | 0.87 | KDM4E (0.57) | MAPTTP53POLBALDH1A1HPGD | |
| SCHEMBL2925364 | 0.82 | HPGD (0.60) | MAPTTP53POLBALDH1A1HPGD | |
| SCHEMBL12030352 | 0.81 | MAPT (0.59) | MAPTTP53POLBALDH1A1HPGD | |
| SCHEMBL983454 | 0.81 | KDM4E (0.60) | MAPTTP53POLBALDH1A1HPGD | |
| SCHEMBL982847 | 0.79 | KDM4E (0.56) | MAPTTP53POLBALDH1A1HPGD | |
| SCHEMBL985056 | 0.79 | ALDH1A1 (0.52) | MAPTTP53POLBALDH1A1HPGD | |
| SCHEMBL12949238 | 0.79 | KDM4E (0.58) | MAPTTP53POLBALDH1A1HPGD | |
| SCHEMBL984002 | 0.78 | MAPT (0.48) | MAPTTP53POLBALDH1A1HPGD | |
| SCHEMBL985548 | 0.77 | MAPT (0.53) | MAPTTP53POLBALDH1A1HPGD | |
| SCHEMBL12949244 | 0.77 | MAPT (0.51) | MAPTTP53POLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217606-A1 | SOLUBILIZED THIAZOLOPYRIDINES | Sirtris Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061453-A1 | SOLUBILIZED THIAZOLOPYRIDINES | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |