Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.41 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CASP2 | P42575 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23698403 | 0.98 | MEN1 (0.42) | MEN1KMT2ASMN1; SMN2HSP90AA1ABCB11 | |
| SCHEMBL2693562 | 0.98 | MEN1 (0.42) | MEN1KMT2ASMN1; SMN2HSP90AA1ABCB11 | |
| SCHEMBL4358559 | 0.98 | MEN1 (0.42) | MEN1KMT2ASMN1; SMN2HSP90AA1ABCB11 | |
| SCHEMBL15901858 | 0.98 | MEN1 (0.42) | MEN1KMT2ASMN1; SMN2HSP90AA1ABCB11 | |
| SCHEMBL3398646 | 0.98 | MEN1 (0.42) | MEN1KMT2ASMN1; SMN2HSP90AA1ABCB11 | |
| Bromide SCHEMBL4362535 | 0.97 | HSP90AA1 (0.44) | MEN1KMT2ASMN1; SMN2RAD52HSP90AA1 | |
| Iodide SCHEMBL2894605 | 0.97 | SMN1; SMN2 (0.42) | MEN1KMT2ASMN1; SMN2HSP90AA1ABCB11 | |
| Bromide SCHEMBL29770293 | 0.97 | HSP90AA1 (0.44) | MEN1KMT2ASMN1; SMN2RAD52HSP90AA1 | |
| SCHEMBL1680333 | 0.97 | MEN1 (0.40) | MEN1KMT2ASMN1; SMN2HSP90AA1ABCB11 | |
| Bromide SCHEMBL4364809 | 0.95 | MEN1 (0.42) | MEN1KMT2ASMN1; SMN2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178889-B1 | CURABLE AND CURED SILICONE RUBBER COMPOSITIONS AND METHODS FOR THEIR PREPARATION USING FUNCTIONALISED SILICA | MOMENTIVE PERFORMANCE MAT INC (US) | 2013-10-02 | — | — | EP | disclosed |
| US-8501856-B2 | Curable silicon-containing compositions possessing high translucency | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-7790829-B2 | Curable and cured silicone rubber compositions and methods therefor | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2010-09-07 | — | — | US | disclosed |
| EP-2178983-A2 | CURABLE SILICON-CONTAINING COMPOSITIONS POSSESSING HIGH TRANSLUCENCY | Momentive Performance Materials Inc. (US) | 2010-04-28 | — | — | EP | disclosed |
| EP-2178889-A1 | CURABLE AND CURED SILICONE RUBBER COMPOSITIONS AND METHODS FOR THEIR PREPARATION USING FUNCTIONALISED SILICA | Momentive Performance Materials Inc. (US) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009011777-A2 | CURABLE SILICON-CONTAINING COMPOSITIONS POSSESSING HIGH TRANSLUCENCY | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2009-01-22 | — | — | WO | disclosed |
| WO-2009011779-A1 | CURABLE AND CURED SILICONE RUBBER COMPOSITIONS AND METHODS FOR THEIR PREPARATION USING FUNCTIONALISED SILICA | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2009-01-22 | — | — | WO | disclosed |
| US-20090018260-A1 | Curable silicon-containing compositions possessing high translucency | MOMENTIVE PERFORMANCE MATERIALS INC. | 2009-01-15 | — | — | US | disclosed |
| US-20090018261-A1 | Curable and cured silicone rubber compositions and methods therefor | MOMENTIVE PERFORMANCE MATERIALS, INC. | 2009-01-15 | — | — | US | disclosed |