Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.53 |
| ▸ | FDPS | P14324 | 18/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4358561 | 0.98 | MEN1 (0.56) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| SCHEMBL29271983 | 0.98 | MEN1 (0.56) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| SCHEMBL28548851 | 0.98 | MEN1 (0.56) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| SCHEMBL2693557 | 0.98 | MEN1 (0.56) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| SCHEMBL3398652 | 0.98 | MEN1 (0.56) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| SCHEMBL23698402 | 0.98 | MEN1 (0.56) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| SCHEMBL15901605 | 0.98 | MEN1 (0.56) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Iodide SCHEMBL15009156 | 0.97 | MEN1 (0.55) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Iodide SCHEMBL15008828 | 0.97 | MEN1 (0.55) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Iodide SCHEMBL2894606 | 0.97 | MEN1 (0.55) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178889-B1 | CURABLE AND CURED SILICONE RUBBER COMPOSITIONS AND METHODS FOR THEIR PREPARATION USING FUNCTIONALISED SILICA | MOMENTIVE PERFORMANCE MAT INC (US) | 2013-10-02 | — | — | EP | disclosed |
| US-8501856-B2 | Curable silicon-containing compositions possessing high translucency | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-7790829-B2 | Curable and cured silicone rubber compositions and methods therefor | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-20090018260-A1 | Curable silicon-containing compositions possessing high translucency | MOMENTIVE PERFORMANCE MATERIALS INC. | 2009-01-15 | — | — | US | disclosed |
| US-20090018261-A1 | Curable and cured silicone rubber compositions and methods therefor | MOMENTIVE PERFORMANCE MATERIALS, INC. | 2009-01-15 | — | — | US | disclosed |