Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | DHPS | P49366 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31391661 | 1.00 | KDM4E (0.55) | KDM4EALDH1A1HPGDHDAC1HDAC4 | |
| SCHEMBL3225584 | 0.88 | GRM5 (0.49) | KDM4EALDH1A1HPGDHDAC1HDAC4 | |
| SCHEMBL29479790 | 0.86 | HDAC1 (0.50) | KDM4EALDH1A1HPGDHDAC1HDAC4 | |
| SCHEMBL2019162 | 0.84 | HDAC1 (0.56) | ALDH1A1HDAC1HDAC4HDAC6PARP1 | |
| SCHEMBL31298892 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL20028546 | 0.82 | HDAC1 (0.58) | ALDH1A1HDAC1HDAC4HDAC6PARP1 | |
| SCHEMBL16850291 | 0.82 | HDAC1 (0.58) | KDM4EHDAC1HDAC4HDAC6PARP1 | |
| SCHEMBL15120603 | 0.82 | HDAC1 (0.55) | HDAC1HDAC4HDAC6PARP1DHPS | |
| SCHEMBL2023743 | 0.82 | HDAC1 (0.55) | HDAC1HDAC4HDAC6PARP1DHPS | |
| SCHEMBL31666975 | 0.82 | HDAC1 (0.60) | KDM4EALDH1A1HPGDHDAC1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115843293-A | Tricyclic compound, preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2023-03-24 | — | — | CN | disclosed |