SCHEMBL29011985

SCHEMBL29011985

COc1cc(C(=O)N2CCC(c3cnc(N)cc3OC)CC2)ncc1OC(F)C(C)C(F)F

nearest known ligand 0.80

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TRPC6 Q9Y210 20/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21045865 0.89 TRPC6 (1.00) TRPC6
SCHEMBL21081159 0.87 TRPC6 (1.00) TRPC6
SCHEMBL21081202 0.87 TRPC6 (1.00) TRPC6
SCHEMBL21045718 0.87 TRPC6 (1.00) TRPC6
SCHEMBL29774007 0.83 TRPC6 (1.00) TRPC6
SCHEMBL21045860 0.83 TRPC6 (1.00) TRPC6
SCHEMBL21045758 0.82 TRPC6 (1.00) TRPC6
SCHEMBL21045698 0.82 TRPC6 (1.00) TRPC6
SCHEMBL21045878 0.81 TRPC6 (1.00) TRPC6
SCHEMBL21045920 0.81 TRPC6 (1.00) TRPC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111527078-B Pyridinecarbonyl derivatives and their therapeutic use as TRPC6 inhibitors 勃林格殷格翰国际公司 2023-06-02 CN disclosed