Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27581022 | 0.80 | LMNA (0.56) | LMNATSHRKMT2AMAPK1MAPT | |
| SCHEMBL18838919 | 0.80 | LMNA (0.56) | LMNATSHRKMT2AMAPK1MAPT | |
| SCHEMBL10275628 | 0.80 | AKT1 (0.54) | LMNAKMT2ARAB9AMEN1MAPK1 | |
| SCHEMBL10275631 | 0.80 | AKT1 (0.54) | LMNAKMT2ARAB9AMEN1MAPK1 | |
| SCHEMBL10439177 | 0.80 | AKT1 (0.54) | LMNAKMT2ARAB9AMEN1MAPK1 | |
| SCHEMBL1877572 | 0.78 | ZDHHC2 (0.49) | LMNAKMT2ARAB9AMEN1MAPT | |
| SCHEMBL1877571 | 0.78 | ZDHHC2 (0.49) | LMNAKMT2ARAB9AMEN1MAPT | |
| SCHEMBL23754765 | 0.78 | TSHR (0.50) | LMNATSHRKMT2ARAB9AMAPK1 | |
| SCHEMBL2502087 | 0.78 | TSHR (0.50) | LMNATSHRKMT2ARAB9AMAPK1 | |
| SCHEMBL8734082 | 0.77 | ELANE (0.59) | LMNAKMT2ARAB9AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148677-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008131276-A1 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-10-30 | — | — | WO | disclosed |
| US-3987051-A | Method for producing 1-unsubstituted pyrazolo[3,4-b]pyridine ketones | E. R. SQUIBB & SONS, INC. (US) | 1976-10-19 | — | — | US | disclosed |