Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | NR1D1 | P20393 | 4/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 2/20 | 0.33 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27768365 | 0.83 | CHEK1 (0.35) | FLT1KDRCHEK1LMNA | |
| SCHEMBL27768559 | 0.82 | MCHR1 (0.35) | FLT1KDRCHEK1LMNA | |
| SCHEMBL12922006 | 0.81 | FLT1 (0.42) | FLT1CHEK1MEN1KMT2ATBXAS1 | |
| SCHEMBL12921998 | 0.80 | CHEK1 (0.46) | FLT1CHEK1LMNA | |
| SCHEMBL29900031 | 0.80 | CHEK1 (0.46) | FLT1CHEK1LMNA | |
| SCHEMBL12922002 | 0.79 | FLT1 (0.45) | FLT1CHEK1MEN1KMT2ALMNA | |
| SCHEMBL28776699 | 0.77 | CHEK1 (0.34) | CHEK1MEN1KMT2ALMNA | |
| SCHEMBL29900079 | 0.74 | FLT1 (0.47) | FLT1MEN1KMT2ANR1D1NR1H3 | |
| SCHEMBL14038918 | 0.73 | CYP1A2 (0.44) | MEN1KMT2ALMNARAD52S1PR1 | |
| SCHEMBL28781348 | 0.73 | MCHR1 (0.39) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115038439-A | Combination cancer therapy with CHK inhibitors | 上海华禹生物科技有限公司 | 2022-09-09 | — | — | CN | claimed |
| CN-115038440-A | Combination cancer therapy with CHK inhibitors | 上海华禹生物科技有限公司 | 2022-09-09 | — | — | CN | claimed |
| CN-115038439-A | Combination cancer therapy with CHK inhibitors | 上海华禹生物科技有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-115038440-A | Combination cancer therapy with CHK inhibitors | 上海华禹生物科技有限公司 | 2022-09-09 | — | — | CN | disclosed |