Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25940158 | 0.91 | PDK2 (0.47) | PDK2SMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL30479039 | 0.91 | PDK2 (0.47) | PDK2SMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL30066370 | 0.88 | LRRK2 (0.46) | ALKTLR9CHRM2CHRM1CHRM4 | |
| SCHEMBL24670613 | 0.88 | LRRK2 (0.46) | ALKTLR9CHRM2CHRM1CHRM4 | |
| SCHEMBL29013163 | 0.85 | SMN1; SMN2 (0.44) | S1PR1NPC1RAB9ACYP4F2CYP4A11 | |
| SCHEMBL29013203 | 0.84 | NEK2 (0.43) | NPC1RAB9ASMN1; SMN2GPR84NEK2 | |
| SCHEMBL25935365 | 0.83 | PDK2 (0.48) | PDK2SMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL27039573 | 0.82 | TLR9 (0.52) | ALKTLR9PDK2TLR7 | |
| SCHEMBL29179826 | 0.81 | CYP4F2 (0.38) | TLR9S1PR1NPC1RAB9ACYP4F2 | |
| SCHEMBL25192126 | 0.80 | S1PR1 (0.40) | S1PR1NPC1RAB9ACYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |