Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 3/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30479023 | 0.91 | HPGD (0.49) | SMN1; SMN2 | |
| SCHEMBL25940005 | 0.91 | HPGD (0.49) | SMN1; SMN2 | |
| SCHEMBL25419096 | 0.89 | GRM5 (0.41) | GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25940006 | 0.89 | ITGB2 (0.38) | GRM5ITGB2ICAM1ITGALGPR84 | |
| SCHEMBL30479018 | 0.89 | ITGB2 (0.38) | GRM5ITGB2ICAM1ITGALGPR84 | |
| SCHEMBL29013177 | 0.88 | FFAR4 (0.47) | GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29013164 | 0.84 | ALK (0.43) | NEK2NPC1RAB9ASMN1; SMN2GPR84 | |
| SCHEMBL25935354 | 0.84 | HPGD (0.50) | SMN1; SMN2 | |
| SCHEMBL30955748 | 0.84 | TLR9 (0.53) | SMPD3 | |
| SCHEMBL29013163 | 0.83 | SMN1; SMN2 (0.44) | NEK2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |