Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.75 |
| ▸ | RAB9A | P51151 | 4/20 | 0.75 |
| ▸ | GAA | P10253 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | XDH | P47989 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289596 | 0.90 | SMN1; SMN2 (0.74) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289408 | 0.88 | SMN1; SMN2 (0.72) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289635 | 0.87 | KDM4E (0.57) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL892234 | 0.86 | RAB9A (1.00) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289699 | 0.83 | KDM4E (0.61) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL290675 | 0.82 | KDM4E (0.62) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289866 | 0.82 | SMN1; SMN2 (0.59) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL290129 | 0.82 | PPARA (0.53) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289411 | 0.81 | KDM4E (0.53) | KDM4ERAB9AGAASMN1; SMN2NPC1 | |
| SCHEMBL289879 | 0.81 | CYP3A4 (0.62) | KDM4ERAB9AGAASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |