Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.39 |
| ▸ | INSR | P06213 | 8/20 | 0.39 |
| ▸ | IGF1R | P08069 | 8/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 2/20 | 0.38 |
| ▸ | GAK | O14976 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | STK10 | O94804 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | FES | P07332 | 2/20 | 0.38 |
| ▸ | YES1 | P07947 | 2/20 | 0.38 |
| ▸ | HCK | P08631 | 2/20 | 0.38 |
| ▸ | ROS1 | P08922 | 2/20 | 0.38 |
| ▸ | FER | P16591 | 2/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29015729 | 0.90 | EGFR (0.42) | EGFRMETALKINSRIGF1R | |
| SCHEMBL29015756 | 0.87 | EGFR (0.44) | EGFRMETALKINSRIGF1R | |
| SCHEMBL29015712 | 0.86 | EGFR (0.49) | EGFRMETALKINSRIGF1R | |
| SCHEMBL24327563 | 0.78 | ALK (0.58) | EGFRMETALKINSRIGF1R | |
| SCHEMBL24327663 | 0.72 | ALK (0.59) | EGFRMETALKINSRIGF1R | |
| SCHEMBL29015781 | 0.70 | ALK (0.47) | EGFRMETALKINSRIGF1R | |
| SCHEMBL21715308 | 0.69 | ALK (0.60) | EGFRMETALKINSRIGF1R | |
| SCHEMBL29015787 | 0.69 | EGFR (0.39) | EGFRALKINSRIGF1RPTK2 | |
| SCHEMBL24326979 | 0.69 | ALK (0.55) | EGFRMETALKINSRIGF1R | |
| SCHEMBL26778373 | 0.69 | ALK (0.69) | EGFRMETALKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116249690-A | Indoline compounds and derivatives as EGFR inhibitors | 百济神州有限公司 | 2023-06-09 | — | — | CN | disclosed |