Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.49 |
| ▸ | MET | P08581 | 3/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 13/20 | 0.47 |
| ▸ | INSR | P06213 | 10/20 | 0.47 |
| ▸ | IGF1R | P08069 | 10/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | STK10 | O94804 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | FES | P07332 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | YES1 | P07947 | 2/20 | 0.44 |
| ▸ | LYN | P07948 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29015756 | 0.93 | EGFR (0.44) | EGFRMETALKINSRIGF1R | |
| SCHEMBL29015739 | 0.86 | EGFR (0.41) | EGFRMETALKINSRIGF1R | |
| SCHEMBL29015729 | 0.86 | EGFR (0.42) | EGFRMETALKINSRIGF1R | |
| SCHEMBL29015781 | 0.84 | ALK (0.47) | EGFRMETALKINSRIGF1R | |
| SCHEMBL21715308 | 0.83 | ALK (0.60) | EGFRMETALKINSRIGF1R | |
| SCHEMBL26778364 | 0.77 | ALK (0.77) | EGFRMETALKINSRIGF1R | |
| SCHEMBL24328498 | 0.76 | ALK (0.64) | EGFRMETALKINSRIGF1R | |
| SCHEMBL1376839 | 0.76 | ZAP70 (0.47) | EGFRMETALKINSRIGF1R | |
| SCHEMBL31592456 | 0.74 | EGFR (0.56) | EGFRMETALKINSRIGF1R | |
| SCHEMBL29661303 | 0.73 | ALK (0.75) | EGFRMETALKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116249690-A | Indoline compounds and derivatives as EGFR inhibitors | 百济神州有限公司 | 2023-06-09 | — | — | CN | disclosed |