Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.57 |
| ▸ | PIM1 | P11309 | 4/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29017654 | 0.82 | DPP4 (0.44) | CNR2DPP4MAP4K4IRAK4HRH4 | |
| SCHEMBL29017783 | 0.82 | CNR2 (0.60) | CNR2PIM1PIM2PIM3DPP4 | |
| SCHEMBL29017658 | 0.80 | CNR2 (0.49) | CNR2CNR1 | |
| SCHEMBL29017678 | 0.78 | CNR2 (0.42) | CNR2PIM1PIM2PIM3DPP4 | |
| SCHEMBL29017649 | 0.78 | CYP1A2 (0.60) | PIM1MAP4K4HRH4 | |
| Lodaxaprine SCHEMBL29388153 | 0.76 | CNR2 (0.67) | CNR2CNR1PTPN11 | |
| Lodaxaprine SCHEMBL2109167 | 0.76 | CNR2 (0.67) | CNR2CNR1PTPN11 | |
| SCHEMBL29637922 | 0.74 | CNR1 (0.47) | CNR2CNR1 | |
| SCHEMBL29017683 | 0.74 | CNR1 (0.47) | CNR2CNR1 | |
| SCHEMBL3390610 | 0.74 | CNR2 (0.56) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478478-B | N- (1- (6- (substituted phenyl) pyridazin-3-yl) piperidin-3-yl) amine/amide derivatives and process for preparing the same | 厦门大学 | 2023-06-13 | — | — | CN | disclosed |
| CN-114478478-A | N- (1- (6- (substituted phenyl) pyridazine-3-yl) piperidine-3-yl) amine/amide derivative and preparation method thereof | 厦门大学 | 2022-05-13 | — | — | CN | disclosed |