SCHEMBL29018646

SCHEMBL29018646

C#CC(C)(C)NCc1ccc(C#N)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 2/20 0.56
CYP19A1 P11511 2/20 0.46
CYP2A6 P11509 2/20 0.46
EPHX2 P34913 1/20 0.46
ALDH1A1 P00352 2/20 0.39
KDM4E B2RXH2 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
HPGD P15428 1/20 0.39
CYP2C19 P33261 1/20 0.39
KIF11 P52732 1/20 0.38
SCN8A Q9UQD0 1/20 0.38
PPARA Q07869 1/20 0.37
KDM1A O60341 1/20 0.37
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
CACNA1G O43497 1/20 0.37
CACNA1B Q00975 1/20 0.37
CYP11B1 P15538 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7926750 0.82 LOXL2 (0.64) LOXL2CYP19A1CYP2A6EPHX2ALDH1A1
SCHEMBL6095262 0.78 CYP3A4 (0.43) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL509578 0.73 LOXL2 (1.00) LOXL2CYP19A1CYP2A6EPHX2ALDH1A1
SCHEMBL20791979 0.72 LOXL2 (0.51) LOXL2CYP19A1CYP2A6EPHX2ALDH1A1
Hydrochloric Acid SCHEMBL8135282 0.71 LOXL2 (0.95) LOXL2CYP19A1CYP2A6EPHX2ALDH1A1
SCHEMBL23879203 0.71 LOXL2 (0.71) LOXL2CYP19A1CYP2A6EPHX2ALDH1A1
SCHEMBL12085987 0.71 LOXL2 (0.39) LOXL2EPHX2ALDH1A1KDM4ECYP2C9
SCHEMBL25588079 0.69 LOXL2 (0.68) LOXL2CYP19A1CYP2A6EPHX2ALDH1A1
SCHEMBL21786654 0.68 LOXL2 (0.73) LOXL2CYP19A1CYP2A6EPHX2ALDH1A1
SCHEMBL1037055 0.68 LOXL2 (0.67) LOXL2CYP19A1CYP2A6EPHX2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116284092-A Iron catalytic system for alkyne compound hydroboration and hydrosilation reaction and application thereof 河北科技大学 2023-06-23 CN disclosed