Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | RICTOR | Q6R327 | 2/20 | 1.00 |
| ▸ | RPTOR | Q8N122 | 2/20 | 1.00 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 1.00 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 1/20 | 1.00 |
| ▸ | FECH | P22830 | 1/20 | 0.67 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ku-0063794 SCHEMBL290211 | 1.00 | MTOR (1.00) | MTORPIK3CAKCNH2RICTORRPTOR | |
| Ku-0063794 SCHEMBL29454796 | 1.00 | MTOR (1.00) | MTORPIK3CAKCNH2RICTORRPTOR | |
| Ku-0063794 SCHEMBL29350060 | 1.00 | MTOR (1.00) | MTORPIK3CAKCNH2RICTORRPTOR | |
| SCHEMBL2926233 | 0.97 | MTOR (0.94) | MTORPIK3CAKCNH2RICTORRPTOR | |
| SCHEMBL14239586 | 0.93 | MTOR (0.86) | MTORPIK3CAKCNH2RICTORRPTOR | |
| SCHEMBL10092312 | 0.92 | MTOR (0.86) | MTORPIK3CAKCNH2RICTORRPTOR | |
| SCHEMBL4748699 | 0.92 | MTOR (0.85) | MTORPIK3CAKCNH2RICTORRPTOR | |
| SCHEMBL22787101 | 0.91 | MTOR (0.84) | MTORPIK3CAKCNH2RICTORRPTOR | |
| SCHEMBL2900826 | 0.91 | MTOR (0.83) | MTORPIK3CAKCNH2RICTORRPTOR | |
| SCHEMBL14089019 | 0.91 | MTOR (0.83) | MTORPIK3CAKCNH2RICTORRPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11471462-B2 | Compositions and methods for detecting and treating diabetes | THE BROAD INSTITUTE, INC. (US) | 2022-10-18 | — | — | US | claimed |
| US-20170049786-A1 | MTOR PATHWAY INHIBITORS FOR TREATING OCULAR DISORDERS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2017-02-23 | — | — | US | claimed |
| US-20120114637-A1 | MTOR PATHWAY INHIBITORS FOR TREATING OCULAR DISORDERS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2012-05-10 | — | — | US | claimed |
| EP-2427174-A1 | MTOR PATHWAY INHIBITORS FOR TREATING OCULAR DISORDERS | Santen Pharmaceutical Co., Ltd (JP) | 2012-03-14 | — | — | EP | claimed |
| JP-2011512395-A | — | — | 2011-04-21 | — | — | JP | claimed |
| US-20110028471-A1 | COMBINATION THERAPY 238 | ASTRAZENECA AB (SE) | 2011-02-03 | — | — | US | claimed |
| EP-2262504-A1 | COMBINATION THERAPY 238 | AstraZeneca AB (SE) | 2010-12-22 | — | — | EP | claimed |
| WO-2010129622-A1 | MTOR PATHWAY INHIBITORS FOR TREATING OCULAR DISORDERS | MACUSIGHT, INC. (US) | 2010-11-11 | — | — | WO | claimed |
| EP-2217234-A2 | COMBINATIONS OF MEK INHIBITORS WITH MTOR INHIBITORS | AstraZeneca AB (SE) | 2010-08-18 | — | — | EP | claimed |
| WO-2009104019-A1 | COMBINATION THERAPY 238 | ASTRAZENECA AB (SE) | 2009-08-27 | — | — | WO | claimed |
| WO-2009050506-A2 | COMBINATION 059 | ASTRAZENECA AB (SE) | 2009-04-23 | — | — | WO | claimed |
| US-20090099174-A1 | COMBINATION 059 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | claimed |
| EP-3474849-B1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DIABETES | BROAD INST INC (US) | 2025-05-21 | — | — | EP | disclosed |
| US-11471462-B2 | Compositions and methods for detecting and treating diabetes | THE BROAD INSTITUTE, INC. (US) | 2022-10-18 | — | — | US | disclosed |
| US-20190350938-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DIABETES | THE BROAD INSTITUTE, INC. (US) | 2019-11-21 | — | — | US | disclosed |
| US-20170049786-A1 | MTOR PATHWAY INHIBITORS FOR TREATING OCULAR DISORDERS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2017-02-23 | — | — | US | disclosed |
| EP-2217234-A2 | COMBINATIONS OF MEK INHIBITORS WITH MTOR INHIBITORS | AstraZeneca AB (SE) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009104019-A1 | COMBINATION THERAPY 238 | ASTRAZENECA AB (SE) | 2009-08-27 | — | — | WO | disclosed |
| WO-2009050506-A2 | COMBINATION 059 | ASTRAZENECA AB (SE) | 2009-04-23 | — | — | WO | disclosed |
| US-20090099174-A1 | COMBINATION 059 | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190350938-A1 | COMPOSITIONS AND METHODS FOR DETECTING AND TREATING DIABETES | SLC2A2, SLC2A1, SLC5A2 | MTOR 3599/4885PIK3CA 3008/4885KCNH2 932/4885 |
| US-20090099174-A1 | COMBINATION 059 | MTOR, RICTOR, MAPK9 | MTOR 1/4885PIK3CA 9/4885KCNH2 4409/4885 |
| US-11471462-B2 | Compositions and methods for detecting and treating diabetes | SLC2A2, SLC2A1, SLC5A2 | MTOR 3599/4885PIK3CA 3008/4885KCNH2 932/4885 |
| US-20110028471-A1 | COMBINATION THERAPY 238 | MTOR, KDR, MET | MTOR 1/4885PIK3CA 8/4885KCNH2 4852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.