Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29021196 | 0.92 | ALDH1A1 (0.41) | HRH4GRM5GRM3ALDH1A1SMN1; SMN2 | |
| SCHEMBL26171964 | 0.84 | GRM5 (0.36) | HRH4GRM5GRM3 | |
| SCHEMBL29134195 | 0.84 | GRM5 (0.36) | HRH4GRM5GRM3ALDH1A1SMN1; SMN2 | |
| SCHEMBL26172049 | 0.84 | GRM5 (0.38) | GRM5ALDH1A1SMN1; SMN2CYP11B2L3MBTL1 | |
| SCHEMBL24207014 | 0.83 | CHRM4 (0.38) | — | |
| SCHEMBL27326706 | 0.83 | CHRM4 (0.44) | HTR1ASMN1; SMN2 | |
| SCHEMBL30694252 | 0.83 | GRM5 (0.38) | HRH4GRM5 | |
| SCHEMBL30511792 | 0.83 | MYC (0.38) | GRM5 | |
| SCHEMBL24207600 | 0.83 | FFAR4 (0.45) | — | |
| SCHEMBL27224957 | 0.83 | HRH4 (0.34) | HRH4GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116847848-A | EGFR degrading agents and methods of use | 百济神州有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-116323580-A | Conjugated degradation (EGFR) of EGFR inhibitors to E3 ligase ligands and methods of use | 百济神州有限公司 | 2023-06-23 | — | — | CN | disclosed |