Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2902175 | 1.00 | ALDH1A1 (0.46) | ALDH1A1MAPTGPR183KMT2AMEN1 | |
| SCHEMBL2905099 | 0.93 | GPR183 (0.42) | ALDH1A1MAPTGPR183KMT2AMEN1 | |
| SCHEMBL2905093 | 0.93 | GPR183 (0.42) | ALDH1A1MAPTGPR183KMT2AMEN1 | |
| SCHEMBL1344345 | 0.91 | ALDH1A1 (0.45) | ALDH1A1MAPTGPR183KMT2AMEN1 | |
| SCHEMBL1344343 | 0.91 | ALDH1A1 (0.45) | ALDH1A1MAPTGPR183KMT2AMEN1 | |
| SCHEMBL2904849 | 0.87 | MEN1 (0.58) | ALDH1A1MAPTGPR183KMT2AMEN1 | |
| SCHEMBL2904853 | 0.87 | MEN1 (0.58) | ALDH1A1MAPTGPR183KMT2AMEN1 | |
| SCHEMBL2903391 | 0.84 | NPC1 (0.57) | GPR183NPC1RAB9A | |
| SCHEMBL2903396 | 0.84 | NPC1 (0.57) | GPR183NPC1RAB9A | |
| SCHEMBL2904336 | 0.84 | MEN1 (0.51) | ALDH1A1MAPTGPR183KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010506-B1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-04 | — | — | EP | disclosed |