Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | TLR4 | O00206 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21818827 | 0.87 | MAPT (0.42) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28629106 | 0.87 | MAPT (0.42) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL31503776 | 0.85 | NR1H2 (0.38) | ALDH1A1NFKB1NFKB2RELATSHR | |
| SCHEMBL3195825 | 0.83 | MAPT (0.46) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL18618384 | 0.80 | MAPT (0.46) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL22620447 | 0.78 | MAPT (0.41) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL17877348 | 0.78 | MAPT (0.44) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2499021 | 0.77 | MAPT (0.43) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL24275820 | 0.76 | MAPT (0.42) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL28266908 | 0.76 | HSD11B1 (0.39) | MAPTKDM4EHSD17B10NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116348453-A | Heteroaromatic carboxamide compounds and uses thereof | 烨辉医药科技(上海)有限公司 | 2023-06-27 | — | — | CN | disclosed |
| WO-2022228302-A1 | HETEROAROMATIC CARBOXAMIDE COMPOUNDS AND ITS USE | BIONOVA PHARMACEUTICALS (SHANGHAI) LIMITED (CN) | 2022-11-03 | — | — | WO | disclosed |