SCHEMBL29024630

SCHEMBL29024630

COC(=O)C(C)(C)Oc1ccc([C@@H](O)c2ccc(Cl)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 6/20 0.56
CYP1A2 P05177 4/20 0.56
CYP3A4 P08684 4/20 0.56
ABCB11 O95342 2/20 0.56
TSHR P16473 2/20 0.56
HTR2A P28223 2/20 0.56
PMP22 Q01453 2/20 0.56
CYP2C19 P33261 3/20 0.55
MEN1 O00255 2/20 0.55
MAPT P10636 2/20 0.55
KMT2A Q03164 2/20 0.55
CYP2D6 P10635 2/20 0.55
CNR1 P21554 7/20 0.53
PPARG P37231 2/20 0.53
CYP2C9 P11712 2/20 0.53
USP2 O75604 1/20 0.53
LMNA P02545 1/20 0.53
ADORA3 P0DMS8 1/20 0.53
ADRB3 P13945 1/20 0.53
HPGD P15428 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29024473 1.00 PPARA (0.56) PPARACYP1A2CYP3A4ABCB11TSHR
SCHEMBL2121452 0.89 PPARA (0.68) PPARACYP1A2CYP3A4ABCB11TSHR
SCHEMBL11434553 0.86 CNR1 (0.73) PPARACYP1A2CYP3A4ABCB11TSHR
SCHEMBL23605918 0.85 CNR1 (0.59) PPARACYP1A2CYP3A4ABCB11TSHR
Fenirofibrate SCHEMBL2733696 0.85 PPARA (0.78) PPARACYP1A2CYP3A4ABCB11TSHR
Fenirofibrate SCHEMBL29024472 0.85 PPARA (0.78) PPARACYP1A2CYP3A4ABCB11TSHR
SCHEMBL11684008 0.84 PPARA (0.62) PPARACYP1A2CYP3A4ABCB11TSHR
SCHEMBL21991231 0.84 PPARA (0.62) PPARACYP1A2CYP3A4ABCB11TSHR
SCHEMBL4755987 0.82 PPARA (0.72) PPARACYP1A2CYP3A4ABCB11TSHR
SCHEMBL10733316 0.80 PPARA (0.53) PPARACYP1A2CYP3A4ABCB11TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116354802-A Preparation method of chiral benzyl secondary alcohol compound 上海毕得医药科技股份有限公司 2023-06-30 CN disclosed