SCHEMBL29024928

SCHEMBL29024928

Nc1ccc2c(N)cncc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 2/20 0.47
CYP3A4 P08684 3/20 0.44
LMNA P02545 3/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
PRKCZ Q05513 2/20 0.43
ALDH1A1 P00352 5/20 0.39
KDM4E B2RXH2 5/20 0.39
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
MAPT P10636 4/20 0.39
PLAU P00749 2/20 0.39
HIF1A Q16665 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
ROCK2 O75116 1/20 0.39
GAA P10253 1/20 0.39
HPGD P15428 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL282060 0.79 EGFR (0.44) EGFRCYP3A4LMNAPRKCZALDH1A1
SCHEMBL31325680 0.79 EGFR (0.44) EGFRCYP3A4LMNAPRKCZALDH1A1
SCHEMBL27192010 0.79 BACE1 (0.41) CYP3A4LMNACYP1A2CYP2D6CYP2C9
SCHEMBL31325689 0.79 EGFR (0.44) EGFRCYP3A4LMNAPRKCZALDH1A1
SCHEMBL30905977 0.79 NR4A2 (0.44) CYP3A4LMNACYP1A2CYP2D6CYP2C9
SCHEMBL8286198 0.79 ALDH1A1 (0.46) CYP3A4LMNACYP1A2CYP2D6CYP2C9
SCHEMBL3060968 0.79 EGFR (0.44) EGFRCYP3A4LMNACYP1A2CYP2D6
SCHEMBL30032995 0.77 CYP3A4 (0.57) CYP3A4LMNACYP1A2CYP2D6CYP2C9
SCHEMBL1325881 0.77 CYP3A4 (0.57) CYP3A4LMNACYP1A2CYP2D6CYP2C9
Hydrochloric Acid SCHEMBL15910696 0.76 CYP3A4 (0.55) CYP3A4LMNACYP1A2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116354879-A Benzamide derivative and application thereof 中国药科大学 2023-06-30 CN disclosed