Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 8/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30428203 | 1.00 | GAA (0.55) | GAATHRBPOLBSMN1; SMN2MEN1 | |
| SCHEMBL5176190 | 0.90 | GAA (0.66) | GAATHRBPOLBSMN1; SMN2MEN1 | |
| SCHEMBL22963745 | 0.85 | GAA (0.56) | GAATHRBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL29397014 | 0.85 | GAA (0.56) | GAATHRBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL25315890 | 0.79 | GAA (0.43) | GAATHRBPOLBMEN1KMT2A | |
| SCHEMBL30493581 | 0.79 | GAA (0.43) | GAATHRBPOLBMEN1KMT2A | |
| SCHEMBL29893035 | 0.79 | MEN1 (0.64) | GAATHRBPOLBSMN1; SMN2MEN1 | |
| SCHEMBL27077382 | 0.79 | MEN1 (0.64) | GAATHRBPOLBSMN1; SMN2MEN1 | |
| SCHEMBL20742976 | 0.77 | POLB (0.57) | GAATHRBPOLBSMN1; SMN2MEN1 | |
| SCHEMBL5579438 | 0.75 | GAA (0.50) | GAATHRBPOLBSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116348115-A | Combination of antibody-drug conjugate and PARP1 selective inhibitor | 阿斯利康(英国)有限公司 | 2023-06-27 | — | — | CN | disclosed |