Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 6/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29893035 | 0.84 | MEN1 (0.64) | POLBSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL27077382 | 0.84 | MEN1 (0.64) | POLBSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL5176190 | 0.78 | GAA (0.66) | POLBSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL30428203 | 0.77 | GAA (0.55) | POLBSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL29026155 | 0.77 | GAA (0.55) | POLBSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL20742910 | 0.75 | GAA (0.52) | MEN1KMT2AGAATHRB | |
| SCHEMBL22142890 | 0.75 | GAA (0.52) | MEN1KMT2AGAATHRB | |
| SCHEMBL17285619 | 0.75 | POLB (0.47) | POLBSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL20655220 | 0.75 | CREBBP (0.58) | POLBSMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL22143056 | 0.74 | SMYD3 (0.53) | MEN1KMT2AGAATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161825-B2 | 4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxamides | BAYER AKTIENGESELLSCHAFT (DE) | 2021-11-02 | — | — | US | disclosed |
| US-20200199083-A1 | 4-OXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE-7-CARBOXAMIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-06-25 | — | — | US | disclosed |
| EP-3668844-A1 | 4-OXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE-7-CARBOXAMIDES | Bayer Aktiengesellschaft (DE) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019034532-A1 | 4-OXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE-7-CARBOXAMIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2019-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200199083-A1 | 4-OXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE-7-CARBOXAMIDES | GABRA5, GABBR2, GABBR1 | POLB 1360/4885SMN1; SMN2 2249/4885MEN1 1451/4885 |
| US-11161825-B2 | 4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxamides | GABRA5, GABBR2, GABBR1 | POLB 1360/4885SMN1; SMN2 2249/4885MEN1 1451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.