Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL29027395 | 1.00 | MAOA (0.45) | MAOADRD2DRD4DRD3KAT8 | |
| SCHEMBL79201 | 0.97 | MAOA (0.47) | MAOADRD2DRD4DRD3KAT8 | |
| SCHEMBL28215975 | 0.94 | MAOA (0.45) | MAOADRD2DRD4DRD3KAT8 | |
| SCHEMBL30532125 | 0.94 | MAOA (0.45) | MAOADRD2DRD4DRD3KAT8 | |
| Benzene SCHEMBL28241649 | 0.94 | MAOA (0.45) | MAOADRD2DRD4DRD3KAT8 | |
| SCHEMBL6284681 | 0.94 | MAOA (0.45) | MAOADRD2DRD4DRD3KAT8 | |
| Fluoride SCHEMBL27944277 | 0.94 | MAOA (0.45) | MAOADRD2DRD4DRD3KAT8 | |
| SCHEMBL27951539 | 0.94 | MAOA (0.45) | MAOADRD2DRD4DRD3KAT8 | |
| Fluoride SCHEMBL29179319 | 0.92 | MAOA (0.44) | MAOADRD2DRD4DRD3KAT8 | |
| Fluoride Ion SCHEMBL31521528 | 0.92 | MAOA (0.44) | MAOADRD2DRD4DRD3KAT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116367862-A | Process for preparing nickel (II) protoporphyrin-I | 阿德格罗生物制药控股有限公司 | 2023-06-30 | — | — | CN | disclosed |