Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.49 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905635 | 0.80 | MAPT (0.71) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL23409004 | 0.79 | MAPT (0.66) | MAPTMEN1KMT2AFFAR1ALDH1A1 | |
| SCHEMBL6692696 | 0.79 | FFAR1 (0.67) | MAPTMEN1KMT2AFFAR1ALDH1A1 | |
| SCHEMBL11935888 | 0.78 | MAPT (0.49) | MAPTMEN1KMT2AFFAR1ALDH1A1 | |
| SCHEMBL2910992 | 0.78 | CYP17A1 (0.56) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL6229701 | 0.78 | HPGD (0.65) | MAPTMEN1KMT2AFFAR1ALDH1A1 | |
| SCHEMBL6696141 | 0.78 | HPGD (0.60) | MAPTMEN1KMT2AFFAR1ALDH1A1 | |
| SCHEMBL3132275 | 0.76 | MAPT (0.49) | MAPTMEN1KMT2AFFAR1ALDH1A1 | |
| SCHEMBL6227614 | 0.76 | MRGPRX1 (0.49) | MAPTMEN1KMT2AFFAR1ALDH1A1 | |
| SCHEMBL6496806 | 0.76 | MAPT (0.49) | MAPTMEN1KMT2AFFAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692109-B1 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS | MEMORY PHARM CORP (US) | 2010-08-18 | — | — | EP | disclosed |
| US-20050222207-A1 | Phosphodiesterase 4 inhibitors, including N-substituted diarylamine analogs | MEMORY PHARMACEUTICAL CORPORATION | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222207-A1 | Phosphodiesterase 4 inhibitors, including N-substituted diarylamine analogs | PDE4A, PDE4B, PDE3B | MAPT 4593/4885MEN1 2325/4885KMT2A 1702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.