Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7027502 | 0.80 | LMNA (0.48) | LMNAKDM4EHTTSMN1; SMN2USP2 | |
| SCHEMBL9983121 | 0.80 | DAGLA (0.40) | LMNAKDM4EHTTSMN1; SMN2USP2 | |
| Hydrochloric Acid SCHEMBL7858307 | 0.79 | LMNA (0.47) | LMNAKDM4EHTTSMN1; SMN2USP2 | |
| SCHEMBL20267237 | 0.76 | KDM4E (0.51) | LMNAKDM4EHTTSMN1; SMN2USP2 | |
| SCHEMBL30906981 | 0.76 | KDM4E (0.51) | LMNAKDM4EHTTSMN1; SMN2USP2 | |
| SCHEMBL28756613 | 0.75 | KDM4E (0.34) | LMNAKDM4EHTTSMN1; SMN2NPC1 | |
| SCHEMBL423447 | 0.74 | CYP2D6 (0.50) | LMNAKDM4EHTTSMN1; SMN2USP2 | |
| SCHEMBL11752845 | 0.73 | ZDHHC2 (0.46) | FAAH | |
| SCHEMBL4885285 | 0.73 | SOAT1 (0.49) | LMNAKDM4EHTTSMN1; SMN2USP2 | |
| SCHEMBL7453009 | 0.73 | SOAT1 (0.49) | LMNAKDM4EHTTSMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212305-A1 | BETA-LACTONE COMPOUNDS | Burnham Institute for Medical Research (US) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009059046-A1 | BETA-LACTONE COMPOUNDS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-05-07 | — | — | WO | disclosed |