Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2905808 | 0.99 | MAPT (0.53) | MAPTPOLBTP53NPC1RAB9A | |
| SCHEMBL2900797 | 0.80 | MAPT (0.46) | MAPTPOLBTP53NPC1RAB9A | |
| SCHEMBL5027039 | 0.80 | MAPT (0.63) | MAPTPOLBTP53NPC1RAB9A | |
| SCHEMBL983700 | 0.78 | MAPT (0.61) | MAPTPOLBTP53NPC1RAB9A | |
| SCHEMBL5740428 | 0.77 | PDE10A (0.53) | MAPTPOLBTP53NPC1RAB9A | |
| SCHEMBL5740439 | 0.77 | MAPT (0.47) | MAPTPOLBTP53NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL2906176 | 0.77 | MAPT (0.59) | MAPTPOLBTP53NPC1RAB9A | |
| SCHEMBL995828 | 0.76 | CSNK1A1 (0.50) | MAPTNPC1RAB9AGAAKDM4E | |
| SCHEMBL11646035 | 0.76 | POLB (0.57) | MAPTPOLBTP53NPC1RAB9A | |
| SCHEMBL30517722 | 0.76 | CSNK1A1 (0.50) | MAPTNPC1RAB9AGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217606-A1 | SOLUBILIZED THIAZOLOPYRIDINES | Sirtris Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009061453-A1 | SOLUBILIZED THIAZOLOPYRIDINES | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |