Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | NNMT | P40261 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2902912 | 0.77 | MAPT (0.54) | MAPTPARP1KDM4ENPC1RAB9A | |
| Hydrochloric Acid SCHEMBL2905808 | 0.76 | MAPT (0.53) | MAPTPARP1KDM4ENPC1RAB9A | |
| SCHEMBL5027039 | 0.74 | MAPT (0.63) | MAPTBCAT2KDM4ENPC1RAB9A | |
| SCHEMBL29787 | 0.71 | MAPT (0.52) | MAPTKDM4ENPC1RAB9A | |
| SCHEMBL5768391 | 0.71 | MAPT (0.57) | MAPTKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL27192381 | 0.71 | TDP1 (0.51) | MAPTPARP1KDM4ENPC1RAB9A | |
| SCHEMBL1984490 | 0.69 | APP (0.61) | KDM4ENPC1RAB9AMEN1KMT2A | |
| SCHEMBL4126586 | 0.69 | PDE10A (1.00) | PDE10A | |
| SCHEMBL3321196 | 0.69 | PDE10A (0.75) | PDE10A | |
| SCHEMBL27714785 | 0.68 | MAPT (0.56) | MAPTBCAT2KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680431-A1 | BENZOTHIAZOLE AND THIAZOLE'5,5-B!PYRIDINE COMPOSITIONS AND THEIR USE AS UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005037845-A1 | BENZOTHIAZOLE AND THIAZOLE[5,5-B] PYRIDINE COMPOSITIONS AND THEIR USE AS UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |