Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 14/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 13/20 | 0.52 |
| ▸ | TSHR | P16473 | 11/20 | 0.52 |
| ▸ | USP2 | O75604 | 10/20 | 0.52 |
| ▸ | LMNA | P02545 | 8/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2253396 | 0.91 | CYP1A2 (0.55) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL2908880 | 0.87 | ACP1 (0.57) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL2250736 | 0.86 | ATM (0.56) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL2250117 | 0.86 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL2901691 | 0.85 | CYP1A2 (0.56) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL2906915 | 0.85 | CYP1A2 (0.50) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL3951241 | 0.83 | AURKA (0.47) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL2246938 | 0.83 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL2251495 | 0.83 | POLB (0.48) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL2906948 | 0.83 | ACP1 (0.53) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825253-B2 | 2-aminoquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-11-02 | — | — | US | disclosed |
| EP-2076495-B1 | QUINOLINE DERIVATIVES WITH 5-HT-BINDING PROPERTIES | HOFFMANN LA ROCHE (CH) | 2010-08-18 | — | — | EP | disclosed |
| EP-2076495-A1 | QUINOLINE DERIVATIVES WITH 5-HT-BINDING PROPERTIES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008037626-A1 | QUINOLINE DERIVATIVES WITH 5-HT-BINDING PROPERTIES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-03 | — | — | WO | disclosed |
| US-20080081907-A1 | 2-AMINOQUINOLINE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2008-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081907-A1 | 2-AMINOQUINOLINE DERIVATIVES | AR, ADRA2C, RCC2 | CYP1A2 27/4885CYP3A4 339/4885CYP2D6 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.