Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 8/20 | 0.39 |
| ▸ | GPR183 | P32249 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2903394 | 1.00 | CCR2 (0.39) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2903392 | 1.00 | CCR2 (0.39) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2904206 | 1.00 | CCR2 (0.39) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2904211 | 1.00 | CCR2 (0.39) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2902524 | 0.93 | GPR183 (0.44) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2904092 | 0.93 | GPR183 (0.44) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2904095 | 0.93 | GPR183 (0.44) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2902527 | 0.93 | GPR183 (0.44) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2902522 | 0.93 | GPR183 (0.44) | CCR2GPR183NPC1RAB9ATDP1 | |
| SCHEMBL2899760 | 0.92 | CCR2 (0.38) | CCR2GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010506-B1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-04 | — | — | EP | disclosed |