Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25364354 | 1.00 | HTRA1 (0.49) | HTRA1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL29035144 | 1.00 | HTRA1 (0.49) | HTRA1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL29880431 | 1.00 | HTRA1 (0.49) | HTRA1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL23452424 | 1.00 | HTRA1 (0.49) | HTRA1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL30882336 | 1.00 | HTRA1 (0.49) | HTRA1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL25366199 | 1.00 | HTRA1 (0.49) | HTRA1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL29035193 | 1.00 | HTRA1 (0.49) | HTRA1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL25054231 | 0.90 | GPR119 (0.46) | HTRA1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL30530634 | 0.88 | NR1H2 (0.49) | HTRA1CYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL29523847 | 0.88 | NR1H2 (0.49) | HTRA1CYP1A2POLBCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964684-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117964683-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-116437913-A | Pharmaceutical compounds for treating complement-mediated disorders | 艾其林医药公司 | 2023-07-14 | — | — | CN | disclosed |