Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 6/20 | 0.37 |
| ▸ | CTSK | P43235 | 5/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25364821 | 0.79 | NOTUM (0.32) | — | |
| SCHEMBL29523614 | 0.79 | CA12 (0.38) | KDM4ACA12CA1CA2CA9 | |
| SCHEMBL29035153 | 0.78 | KDM4A (0.37) | KDM4ACA12CA1CA2CA9 | |
| SCHEMBL29523802 | 0.78 | KDM4A (0.37) | KDM4ACTSKCA12CA1CA2 | |
| SCHEMBL31751451 | 0.76 | KDM4A (0.38) | KDM4ANSD2CTSSCTSKCA1 | |
| SCHEMBL3154474 | 0.75 | TRPA1 (0.46) | TRPA1KDM4ANSD2CTSSCTSK | |
| SCHEMBL31751696 | 0.75 | KDM4A (0.37) | KDM4ANSD2CTSSCTSKCA1 | |
| SCHEMBL29523586 | 0.75 | CA1 (0.35) | KDM4ACA12CA1CA2CA9 | |
| SCHEMBL588780 | 0.75 | KDM4A (0.43) | KDM4ACTSSCTSKCA12CA1 | |
| SCHEMBL6928939 | 0.74 | TRPA1 (0.54) | TRPA1KDM4ANSD2CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4216946-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | Achillion Pharmaceuticals, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| CN-116437913-A | Pharmaceutical compounds for treating complement-mediated disorders | 艾其林医药公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022066774-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS | ACHILLION PHARMACEUTICALS, INC. (US) | 2022-03-31 | — | — | WO | disclosed |