Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 12/20 | 0.71 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29035853 | 0.85 | PIK3C3 (0.63) | PIK3C3MAPK10MAPK8 | |
| SCHEMBL20765374 | 0.85 | PIK3C3 (0.77) | PIK3C3NPY5R | |
| SCHEMBL29701003 | 0.85 | PIK3C3 (0.77) | PIK3C3NPY5R | |
| SCHEMBL26612404 | 0.84 | PIK3C3 (0.79) | PIK3C3KIT | |
| SCHEMBL20774921 | 0.83 | PIK3C3 (0.80) | PIK3C3CYP3A4 | |
| SCHEMBL20765429 | 0.83 | PIK3C3 (1.00) | PIK3C3MAPK10MEN1CYP1A2CYP3A4 | |
| SCHEMBL20764978 | 0.82 | PIK3C3 (0.78) | PIK3C3CYP3A4 | |
| SCHEMBL20765433 | 0.81 | PIK3C3 (1.00) | PIK3C3CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL20765560 | 0.81 | PIK3C3 (1.00) | PIK3C3 | |
| SCHEMBL22408453 | 0.81 | PIK3C3 (1.00) | PIK3C3CYP3A4KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118201619-A | Combination therapy of VPS34 inhibitors with STING agonists for the treatment of cancer | 德西费拉制药有限责任公司 | 2024-06-14 | — | — | CN | claimed |
| CN-117255686-A | Antiviral activity of VPS34 inhibitors | 德西费拉制药有限责任公司 | 2023-12-19 | — | — | CN | claimed |
| CN-118201619-A | Combination therapy of VPS34 inhibitors with STING agonists for the treatment of cancer | 德西费拉制药有限责任公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-117255686-A | Antiviral activity of VPS34 inhibitors | 德西费拉制药有限责任公司 | 2023-12-19 | — | — | CN | disclosed |
| CN-116041321-A | Pyridinamine-pyridone compounds and pyrimidinamine-pyridone compounds | 思普瑞特生物科学公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-116041320-A | Pyridinamine-pyridone compounds and pyrimidinamine-pyridone compounds | 思普瑞特生物科学公司 | 2023-05-02 | — | — | CN | disclosed |