Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.56 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.56 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.56 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.56 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.56 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.56 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.56 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.56 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.56 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.56 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.56 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.56 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.56 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.56 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2903617 | 1.00 | CYP1A2 (0.61) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2905629 | 0.90 | HDAC8 (0.62) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2905625 | 0.90 | HDAC8 (0.62) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2905952 | 0.89 | ITGB1 (0.49) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2905957 | 0.89 | ITGB1 (0.49) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL23486659 | 0.88 | CYP2D6 (0.62) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL21422356 | 0.86 | HDAC8 (0.62) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2906870 | 0.86 | TACR1 (0.53) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2900002 | 0.86 | TACR1 (0.53) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2900007 | 0.86 | TACR1 (0.53) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763507-B1 | ALPHA-AMINO ACID DERIVATES WITH ANTIINFLAMMATORY ACTIVITY | ITALFARMACO SPA (IT) | 2010-08-11 | — | — | EP | claimed |
| US-7635788-B2 | Alpha-amino acid derivatives with antiinflammatory activity | ITALFARMACO SPA (IT) | 2009-12-22 | — | — | US | claimed |
| US-20080076807-A1 | Alpha-Amino Acid Derivatives with Antiinflammatory Activity | ITALFARMACO SPA (IT) | 2008-03-27 | — | — | US | claimed |
| EP-1763507-B1 | ALPHA-AMINO ACID DERIVATES WITH ANTIINFLAMMATORY ACTIVITY | ITALFARMACO SPA (IT) | 2010-08-11 | — | — | EP | disclosed |
| US-7635788-B2 | Alpha-amino acid derivatives with antiinflammatory activity | ITALFARMACO SPA (IT) | 2009-12-22 | — | — | US | disclosed |
| US-20080076807-A1 | Alpha-Amino Acid Derivatives with Antiinflammatory Activity | ITALFARMACO SPA (IT) | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076807-A1 | Alpha-Amino Acid Derivatives with Antiinflammatory Activity | TNF, NFKBIA, IFNG | CYP1A2 4090/4885CYP3A4 4661/4885CYP2D6 4293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.